Complete the game on Survivor difficulty without using a Vita-chamber

The player has completed the game on the Hard difficulty setting

The player has completed the game without harvesting any Little Sisters

Find every audio diary

Acquire all upgrades for all weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Fully research the Rosie

Fully upgrade four weapons

Fully research the Little Sister

The player has fully upgraded three weapons

Hit the jackpot at a slot machine

Fully research the Houdini Splicer